The best solution for those dreaded cold sore outbreaks!
Robinson's Remedies Lip Repair was invented by professional trumpet player Ken Robinson, a lifelong cold sore sufferer, who almost ended his career after experiencing a devastating outbreak. Lip Repair can be used every day because it prevents AND treats cold sores. Tough on cold sores and fever blisters, Lip Repair contains five anti-viral ingredients! And yet it is gentle on your lips with eight moisturizers that help relieve dry, cracked and chapped lips.
You will love how great your lips will feel and, with cold sore outbreaks, you will be amazed how quickly your symptoms are relieved. Simply use it a couple of times daily as a regular lip balm. When you feel an outbreak come or already have one, apply every waking hour to the affected area.
No need for prescriptions or those expensive one-off treatments. So why worry about cold sore outbreaks? We've got you covered!
Kenny Robinson is a professional trumpet player and lifelong cold sore suffer. He tried every treatment available for his potentially career ending condition. Nothing worked the way he needed it to. After eight years of research he developed a formula that treats and prevents cold sores with daily use. It worked great and customers have thanked him for making it. We called it Lip Repair.
But he still wasn’t satisfied. He knew that if he kept working on it with our team of expert formulators they could make it even better. And they have!
Lip Repair Enhanced is the only lip balm that is great for your lips yet tough on your cold sores. With five anti-viral ingredients, you can use Lip Repair Enhanced daily to prevent cold sores from forming. And if you get one, you will be amazed at how fast your symptoms simply disappear! Simply apply it every waking hour and don’t use anything else. It even contains eight moisturizers that relieve dry, cracked and chapped lips and three anti-inflammatories that quickly reduce swelling.
So if you get cold sores, relax! We have you covered.
The following information was researched and prepared by Amanda Vickers, Director United States Botanical Safety Laboratory (USBSL) in a paper titled: “3-Fold Activity Robinson’s Remedies Lip Repair”. USBSL formulates our products.
I. Penetrate
St. John’s Wort (Hypericum perforatum in this case) has two well-known light- mediated anti-viral constituents, hypericin and pseudohypericin. Under ideal conditions (exposure to light), the antiviral effects of hypericin have been well- documented.1,2 It is likely that discrepancies existing in the clinical literature regarding antiviral activity of this ingredient, those which indicate a lack of HSV- inhibition for hypericin, are due to non-ideal conditions in which the hypericin was not photoactivated during treatment protocol.3,4 Robinson’s remedies uses a hydro- ethanolic extract of St. John’s Wort to rapidly penetrate the skin surface in addition to an infused oil of St. John’s Wort, suitable for the care of damaged, sensitive skin.
Lemonbalm (Melissa officinalis L.) is used as an antiviral, specifically for treating cold sores5. Lemonbalm has shown to prevent replication of herpes simplex virus type 2 in HEp-2 cells, as well as inhibit viral infectivity in both herpes simplex virus type 1 and 26. Lemonbalm is able to exert a direct antiviral effect on the herpes virus by affecting attachment and penetration of the virus to the host cells.7,8
The cellular ratio of the amino acids arginine and lysine has been shown in tissue culture studies to determine whether or not a virus is able to direct a host cell to create viral capsids at the expense of host cell histones5. In a lysine-heavy cell, viral replication is suppressed and the viral pathogenicity of the herpes simplex virus is greatly reduced.9 The inclusion of lysine, which is water-soluble, in a topical application, is intended to provide cells at the site of a herpes outbreak with a localized source of extracellular lysine in the event that these cells are lysine-poor.
The use of Glyceryl laurate in Robinson’s Remedies’® Lip Repair is three-fold. First, it is used as a co-emulsifer that has been shown to be nonirritating and is not a photosensitizer.10 Second, Glyceryl laurate helps penetrate through the skin’s surface. This helps carry active ingredients in the Lip Repair to treat the cold sore at its source. 11 Third, glyceryl laurate is known as monolaurin, a dietary supplement with GRAS (Generally Recognized As Safe) status by the Food and Drug Administration.12 Monolaurin has antibacterial and antivirial effects. Monolaurin has been shown to inactivate the lipid-coated viruses, such as the Herpes simplex virus.13,14
II. Protect
UV radiation damage is one trigger for sores of the lip and mouth region, including cold sore outbreaks and canker sores.15,16 Raspberry and coconut oils are natural plant oils with absorbance spectra in partially overlapping portions of the UV spectrum responsible for most sun-induced skin damage17. Robsinson’s Remedies makes no claims of a specific SPF; however, these oils’ primary role in the current formula is to protect skin from the stress caused by UV exposure–raspberry and coconut oils have nourishing and protective activities that may protect skin from the oxidative damage that normally occurs during UV radiation exposure.
Similarly, olive (Olea Europea) leaf extract also helps protect skin from stress caused by UV exposure. Olive leaf extract is the richest source in olive phenolic compounds such as oleuropein, hydroxytyrosol, and tyrosol. 18 “These phenolic compounds present antimicrobial, anticarcinogenic, anti-inflammatory and antioxidant activities”19.
Behenyl alcohol or Docosanol is a natural fatty alcohol that can be used as an alternative to wax and as an emulsifier. Docosanol has been reported to show substantial inhibitory effects on the replication of herpes simplex virus. 20 It is the active ingredient in the well-known antiviral Abreva ® . Docosanol protects the potential target cells by interfering with early intracellular events preventing viral entry and thus replication of the virus.21
Both tea tree (Melaleuca alternifolia) and peppermint (Mentha x piperita) essential oils are a widely recognized as having broad spectrum antimicrobial activity.22,23
Leucidal Liquid and AMTicide Coconut are included in the Robinson’s Remedies’ Lip Repair as natural preservatives. Leucidal Liquid is based on an antimicrobial peptide originally derived from Leuconostoc kimchii, which restricts microbial growth by acidifying its environment. Leucidal Liquid has also been shown to provide skin moisturization properties.24 AMTicide Coconut is created by fermenting Coconut (Cocos nucifera) fruit with Lactocacillus, which restricts fungal growth by disrupting the cellular structures of fungus. AMTicide Coconut also offers moisturizing and conditioning benefits.25
Butylated hydroxytoluene (BHT): The CRC Handbook (1992) classifies butylated BHT as an antioxidant, which is generally recognized as safe (USDA GRAS-listed) at the following levels:
• Food: <.02% total fat and oil (flavorings and essential oils can contain up to .5%)
• Drugs: <.2%
• Cosmetics: 0.01-0.1%
The FDA’s regulatory listing for injestible BHT lists a “no-effect” level as being equivalent to 50mg/kg of body weight per day. In the present formula, an entire 8- ml tube of lip repair contains approximately 8ug of BHT. With a “no-effect” level for a 70kg adult at 3500mg per day, consumption of an entire tube of Lip Repair would be on the order of 1/(4 X 106) of the “no effect” dose.
The information on the metabolism and toxicology of BHT is extensive. There is ample evidence of efficacy of this compound as an antioxidant. It has been suggested that BHT in fatty tissue may even have some effect similar to that of vitamin E. There are some data to indicate that BHT in diets reduces the incidence of certain tumors and the rate of fetal absorption in the rat. The available evidence does not support the view that BHT interferes in any specific way with cellular metabolism. There is no evidence that demonstrates that BHT causes frank biochemical lesions in the liver; moreover, it is obvious that high doses of BHT are needed to induce biochemical alterations. With 0.1% BHT in the diet in rats there are differing data in the literature concerning the effect of such treatment on liver growth and liver enzymes. At 0.05 % in the diet, no toxic effects are discernible. This “no-effect level” is equivalent to 50 mg per kg per day.26
A 1985 animal study evaluated the effect of topical treatment with BHT (5, 10, or 15%) on the recurrence and severity of lesion outbreaks in guinea pigs inoculated with genital herpes simplex virus, demonstrating a reduction in lesion duration during the first outbreak after inoculation:
“Treatment with placebo, 5%, 10%, or 15% BHT was initiated 48 h after viral inoculation and continued 4 times daily for 15 days. During primary infection no differences in maximum lesion severity or titers of virus in lesions were observed, however, lesion duration was reduced in BHT-treated animals resulting in a significantly smaller lesion score-day area under the reporting curve. In a second experiment using U.S.P. mineral oil as an additional placebo, BHT placebo and 15% BHT in a double blind trial, similar results were obtained.27”
In hairless mice infected with herpes simplex virus type 1, BHT was found to be effective in reducing the clearance time of cutaneous lesions when applied topically to the infected area (information on dosage not available to public at this time).28
III. Soothe
Arnica (Arnica MontanaI L.) flower infused oil makes up 2% of our total formula, or about 8% of our oil phase. In addition, we add a concentrated arnica flower CO2 extract to the arnica infused oil to increase potency. It must be noted that much of the literature finding inconclusive results for arnica in reduction of swelling and healing time is not conducted on a therapeutic dose of the plant constituents as is used in this formula, but on extremely dilute homeopathic preparations. Lip repair uses not homeopathic arnica, but a topical infused oil and CO2 extract. Extracts of arnica that include functional doses of the herb (between 1:10 and 1:100 herb weight to final volume) have been clinically shown to reduce painful swelling after surgeries and to increase healing time29,30. In this formula arnica is used to reduce painful swelling that accompanies early onset cold sores and to restore fluidity to the tissues surrounding a lesion.
Ahiflower ® (Buglossoides arvensis) seed oil is a safe and sustainable addition of essential Omega 3 fatty acids in Robinson’s Remedies Lip Repair. Omega 3s helps reduce inflammation, as well as moisturize your skin. 31,32
Glycerin is a naturally occurring sugar alcohol, which is one of the most commonly used and safe humectants, cosmetic ingredients that attract water from the air to the skin, causing a moisturizing effect. Glycerin is also more stable than water, and is bacteriostatic. Robinson’s Remedies uses only USP, vegetable-derived glycerin in Lip Repair and all its skin repair products. Glycerin is also approved by the FDA for use as a skin protectant active for use in the case of fever blisters and cold sores.
Glyceryl Stearate Citrate, Polyglyceryl-3 Stearate, Hydrogenated Lecithin and C12- 16 alcohols: These phospholipid emulsifiers create the creamy consistency of Lip Repair, and act as a protective second skin when applied to the lips, entrapping the nutritive and active oils of Lip Repair on the skin’s surface, while allowing the water- soluble lysine and St. John’s Wort extract to penetrate. Lysolecithin and Sclerotium Gum and Xanthan Gum and Pullulan also help to stabilize the emulsion, while providing a smooth, but non greasy feel on application.33 Potassium cetyl phosphate is an emulsifier and stabilizer, which are vital to a formulation to ensure that it maintains its homogenous mixture.
The herb responsible for the sweet flavor of Robinson’s Remedies’ Lip Repair is known as the sweet leaf, Stevia rebaudiana (Bertoni) Bertoni a plant of the Asteraceae family which is used in traditional cultures of Paraguay for sweetening teas such as yerba mate. Now, stevia is widely available under a plethora of brand names, with highly purified Rebaudioside A preparations being granted GRAS status in the US in 2009. Robinson’s Remedies uses a high quality food-grade stevia extract. In addition, stevia has been found to have anti-microbial and anti- inflammatory effects in vitro.34,35
Manuka honey is a monofloral honey, produced from the nectar of the Manuka honey bush, and is referred to as the “gold standard” of honey.36 The honey was added to Robinson’s Remedies’ Lip Repair to help soothe skin by decreasing inflammation and exudation that is common with cold sores. Honey has also been shown to be a safe and effective way to decrease the healing time of herpes simplex lesions. 37
TRADEMARKS
Robinson’s Remedies is a registered trademark of RR Health LLC
Abreva is a registered trademark of GlaxoSmithKline PLC
Ahiflower is a registered trademark of Technology Crops, LLC
Footnotes:
1 Hudson, J. B., I. Lopez-Bazzocchi, and G. H. N. Towers. “Antiviral activities of hypericin.” Antiviral research 15.2 (1991): 101-112.
2 Cohen, P. A., J. B. Hudson, and G. H. N. Towers. “Antiviral activities of anthraquinones, bianthrones and hypericin derivatives from lichens.” Experientia 52.2 (1996): 180-183.
3 Hudson, J. B., I. Lopez-Bazzocchi, and G. H. N. Towers. “Antiviral activities of hypericin.” Antiviral research 15.2 (1991): 101-112.
4 Lopez‐Bazzocchi, I., J. B. Hudson, and G. H. N. Towers. “Antiviral activity of the photoactive plant pigment hypericin.” Photochemistry and photobiology 54.1 (1991): 95-98.
5 Moradkhani, H., Sargsyan, E., Bibak, H., Naseri, B., Sadat-Hosseini, M., Fayazi-Barjin, A., & Meftahizade, H. (2010). Melissa officinalis L., a valuable medicine plant. J. Med. Plants Res, 4, 2753-2759.
6 Allahverdiyev, A., Duran, N., Ozguven, M., & Koltas, S. (2004). Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2. Phytomedicine, 11(7-8), 657-661.
7 Schnitzler, P., Schuhmacher, A., Astani, A., & Reichling, J. (2008). Melissa officinalis oil affects infectivity of enveloped herpesviruses. Phytomedicine, 15(9), 734-740.
8 Astani, A., Heidary Navid, M., & Schnitzler, P. (2014). Attachment and Penetration of Acyclovir‐resistant Herpes Simplex Virus are Inhibited by Melissa officinalis Extract. Phytotherapy research, 28(10), 1547-1552.
9 Griffith, RichardS, et al. “Success of L-lysine therapy in frequently recurrent herpes simplex infection.” Dermatology 175.4 (1987): 183-190.
10 Raposo, S., Salgado, A., Gonçalves, L., Pinto, P. C., Urbano, M., & Ribeiro, H. M. (2013). Safety assessment and biological effects of a new cold processed SilEmulsion for dermatological purpose. BioMed research international, 2013.
11 Final Report of the Amended Safety Assessment of Glyceryl Lau rate, Glyceryl Lau rate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate1. (2004). International Journal of Toxicology, 23(2_suppl), 55–94. doi: 10.1080/10915810490499064
12 CHAPTER, I. CFR-Code of Federal Regulations Title 21.
13 Lieberman, S., Enig, M. G., & Preuss, H. G. (2006). A review of monolaurin and lauric acid: natural virucidal and bactericidal agents. Alternative & Complementary Therapies, 12(6), 310-314.
14 HIERHOLZER, J. C., & KABARA, J. J. (1982). IN VITRO EFFECTS OF MONOLAURIN COMPOUNDS ON ENVELOPED RNA AND DNA VIRUSES 1. Journal of Food Safety, 4(1), 1-12.
15 Wheeler Jr, Clayton E. “The herpes simplex problem.” Journal of the American Academy of Dermatology 18.1 (1988): 163-168.
16 Esmann, Jørgen. “The many challenges of facial herpes simplex virus infection.” Journal of antimicrobial Chemotherapy 47.suppl 1 (2001): 17-27.
7 Schnitzler, P., Schuhmacher, A., Astani, A., & Reichling, J. (2008). Melissa officinalis oil affects infectivity of enveloped herpesviruses. Phytomedicine, 15(9), 734-740.
8 Astani, A., Heidary Navid, M., & Schnitzler, P. (2014). Attachment and Penetration of Acyclovir‐resistant Herpes Simplex Virus are Inhibited by Melissa officinalis Extract. Phytotherapy research, 28(10), 1547-1552.
9 Griffith, RichardS, et al. “Success of L-lysine therapy in frequently recurrent herpes simplex infection.” Dermatology 175.4 (1987): 183-190.
10 Raposo, S., Salgado, A., Gonçalves, L., Pinto, P. C., Urbano, M., & Ribeiro, H. M. (2013). Safety assessment and biological effects of a new cold processed SilEmulsion for dermatological purpose. BioMed research international, 2013.
11 Final Report of the Amended Safety Assessment of Glyceryl Lau rate, Glyceryl Lau rate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate1. (2004). International Journal of Toxicology, 23(2_suppl), 55–94. doi: 10.1080/10915810490499064
12 CHAPTER, I. CFR-Code of Federal Regulations Title 21.
13 Lieberman, S., Enig, M. G., & Preuss, H. G. (2006). A review of monolaurin and lauric acid: natural virucidal and bactericidal agents. Alternative & Complementary Therapies, 12(6), 310-314.
14 HIERHOLZER, J. C., & KABARA, J. J. (1982). IN VITRO EFFECTS OF MONOLAURIN COMPOUNDS ON ENVELOPED RNA AND DNA VIRUSES 1. Journal of Food Safety, 4(1), 1-12.
15 Wheeler Jr, Clayton E. “The herpes simplex problem.” Journal of the American Academy of Dermatology 18.1 (1988): 163-168.
16 Esmann, Jørgen. “The many challenges of facial herpes simplex virus infection.” Journal of antimicrobial Chemotherapy 47.suppl 1 (2001): 17-27.
17 Oomah, B. Dave, et al. “Characteristics of raspberry (< i> Rubus idaeus</i> L.) seed oil.” Food Chemistry 69.2 (2000): 187-193.
18 De Bock, M., Thorstensen, E. B., Derraik, J. G., Henderson, H. V., Hofman, P. L., & Cutfield, W. S. (2013). Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract. Molecular nutrition & food research, 57(11), 2079-2085.
19 Ribeiro, Ana Sofia, et al. “Main benefits and applicability of plant extracts in skin care products.” Cosmetics 2.2 (2015): 48-65.
20 Katz, D. H., Marcelletti, J. F., Khalil, M. H., Pope, L. E., & Katz, L. R. (1991). Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex. Proceedings of the National Academy of Sciences, 88(23), 10825-10829.
21 Pope, L. E., Marcelletti, J. F., Katz, L. R., Lin, J. Y., Katz, D. H., Parish, M. L., & Spear, P. G. (1998). The anti-herpes simplex virus activity of n-docosanol includes inhibition of the viral entry process. Antiviral research, 40(1-2), 85-94.
22 Cox, S. D., et al. “The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil).” Journal of applied microbiology 88.1 (2000): 170-175.
23 Hammer, Katherine A., C. F. Carson, and T. V. Riley. “Antimicrobial activity of essential oils and other plant extracts.” Journal of applied microbiology 86.6 (1999): 985-990.
24 Leucidal® Liquid. (n.d.). Retrieved from https://activemicrotechnologies.com/product/leucidal-liquid/
25 AMTicide® Coconut. (n.d.). Retrieved from https://activemicrotechnologies.com/product/ amticide-coconut/
26 Butylated Hydroxytoluene—FDA Proposed Rule, Vol 42, No. 104, Federal Register, page 27606, May 1977
27 Richards, James T., Mary Ellen Katz, and Earl R. Kern. “Topical butylated hydroxytoluene treatment of genital herpes simplex virus infections of guinea pigs.” Antiviral research 5.5 (1985): 281-290.
28 Keith, Alec D., et al. “The antiviral effectiveness of butylated hydroxytoluene on herpes cutaneous infections in hairless mice.” Experimental Biology and Medicine 170.2 (1982): 237-244.
29 Huber, Roman, et al. “Arnica and stinging nettle for treating burns–A self- experiment.” Complementary therapies in medicine 19.5 (2011): 276-280.
30 Kučera, Miroslav, et al. “Arnica/Hydroxyethyl salicylate combination spray for ankle distortion: A four-arm randomised double-blind study.” Pain research and treatment 2011 (2011).
31 Cumberford, G., & Hebard, A. (2015). Ahiflower oil: A novel non‐GM plant‐ based omega‐3+ 6 source. Lipid Technology, 27(9), 207-210.
32 Prasad, P., Savyasachi, S., & Reddy, L. P. A. (2019). Physico-chemical Characterization, Profiling of Total Lipids and Triacylglycerol Molecular Species of Omega-3 Fatty Acid Rich B. arvensis Seed Oil from India. Journal of oleo science, 68(3), 209-223.
33 Moldovan, M., Lahmar, A., Bogdan, C., Părăuan, S., TOMUŢĂ, I., & CRIŞAN, M. (2017). Formulation and evaluation of a water-in-oil cream containing herbal active ingredients and ferulic acid. Clujul Medical, 90(2), 212.
34 Jayaraman, Sathishkumar, Muthu Saravanan Manoharan, and Seethalakshmi Illanchezian. “In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts.” Tropical Journal of Pharmaceutical Research 7.4 (2008): 1143-1149.
35 Boonkaewwan, Chaiwat, Chaivat Toskulkao, and Molvibha Vongsakul. “Anti- inflammatory and immunomodulatory activities of stevioside and its metabolite steviol on THP-1 cells.” Journal of agricultural and food chemistry 54.3 (2006): 785- 789.
36 Ahmed, S., & Othman, N. H. (2013). Review of the medicinal effects of tualang honey and a comparison with manuka honey. The Malaysian journal of medical sciences: MJMS, 20(3), 6.
37 Al-Waili, N. S. (2004). Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions. Medical Science Monitor, 10(8), MT94-MT98.
When should I use LIP REPAIR ENHANCED?
Lip Repair Enhanced may be used regularly as any normal lip balm. If you have a cold sore or feel one coming, apply every waking hour. Do not use other remedies including prescriptions as they may inhibit the efficacy of Lip Repair.
How do I apply LIP REPAIR ENHANCED?
Apply with the slanted applicator tip, a clean finger or with a Q-Tip.
Can I use LIP REPAIR ENHANCED if I already have a cold sore?
Yes. LIP REPAIR works even after a blister has developed. Apply it at least every waking hour making sure not to use any other remedy including prescription medication. These may lessen Lip Repair’s effectiveness.
Will LIP REPAIR ENHANCED help to prevent future outbreaks?
Yes, when used daily.
How does LIP REPAIR ENHANCED differ from other cold sore products?Lip Repair Enhanced is formulated to PREVENT cold sores with daily use. It has ingredients that only treat cold sores, but make your lips feel soft and supple.
What are the ingredients in LIP REPAIR ENHANCED?
Please refer to the scientific paper which not only lists our ingredients but the scientific reason for including them in our formulation.
Is LIP REPAIR ENHANCED tested on animals?
No, LIP REPAIR does not participate in animal testing.
Can I wear lipstick while using LIP REPAIR ENHANCED?
Yes, apply LIP REPAIR first, let your lips absorb the product before applying lipstick.
Can I use LIP REPAIR ENHANCED if I don’t have a cold sore?
Yes, use LIP REPAIR to moisturize and prevent dry, cracked and chapped lips.
COPING WITH COLD SORE OUTBREAKS
By KEN ROBINSON – founder of Robinson’s Remedies
Cold sores have been plaguing people of all ages, races, and lifestyles since the late 1800’s. Also known as fever blisters, cold sores are medically referred to as the Herpes Simplex Virus (HSV-1). HSV-1 is commonly recognized as a series of small blisters that form on the lips or around the corner of the mouth. Throughout the duration of the illness, these blisters will bubble, break open and leak a clear fluid, eventually resulting in a scab after a few days. Left untreated, the blisters commonly take approximately three weeks to completely heal from the onset of each episode.
HSV-1 is known to be extremely contagious and can be contracted from an intimate interaction with an infected patient. After the disease is contracted, it lays dormant in the upper part of the spine until reappearing as a flare up. Flare ups are not the same for every patient: each individual will react differently to the virus. Some with HSV-1 are immune to the virus, while others will suffer from several outbreaks a year. Several factors will encourage viral growth and cause an outbreak, including stress, illness, injury, a weakened immune system, or too much exposure to sunlight. When a patient has too much of the amino acid arginine along with too little of the amino acid lysine, outbreaks can occur as well.
Diet can also play a large role when triggering an outbreak. An overly acidic system – drinking orange juice, consuming sugar – are great catalysts to the outbreak of a cold sore. By incorporating foods rich in lysine into the diet, including most fresh vegetables and fruits, a patient can prevent outbreaks. Lysine-rich foods include pears, figs, tomatoes and apricots. A balanced mix of dairy, protein and chicken or vegetable broth has also helped with preventative methods of consistent outbreaks.
Positive ions can also make your body viral. Positive ions are found in the aftermath of a thunderstorm. In fact, most home air purifiers have a built-in negative ion generator, which is another preventative method to take.
At the onset of a cold sore, a lipid envelope surrounds the virus, which makes it harder for any chemical to reach and treat the virus directly. Robinson’s Remedies Lip Repair contains a unique formula that naturally penetrates this lipid envelope, in turn rapidly relieving the symptoms of a cold sore. Using Robinson’s Remedies Lip Repair daily will create an unwelcome environment for a cold sore.
Unfortunately there isn’t a cure for HSV-1, but that doesn’t mean you have to be prisoner to the disease. Figure out what makes you happy, learn how to live with less stress, know your triggers, and act quickly at the onset of an outbreak. A healthy combination of all these elements will make living with HSV-1 completely manageable.
Lip Repair Anti-Viral Cream for Lips
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The best solution for those dreaded cold sore outbreaks!
Robinson's Remedies Lip Repair was invented by professional trumpet player Ken Robinson, a lifelong cold sore sufferer, who almost ended his career after experiencing a devastating outbreak. Lip Repair can be used every day because it prevents AND treats cold sores. Tough on cold sores and fever blisters, Lip Repair contains five anti-viral ingredients! And yet it is gentle on your lips with eight moisturizers that help relieve dry, cracked and chapped lips.
You will love how great your lips will feel and, with cold sore outbreaks, you will be amazed how quickly your symptoms are relieved. Simply use it a couple of times daily as a regular lip balm. When you feel an outbreak come or already have one, apply every waking hour to the affected area.
No need for prescriptions or those expensive one-off treatments. So why worry about cold sore outbreaks? We've got you covered!
Kenny Robinson is a professional trumpet player and lifelong cold sore suffer. He tried every treatment available for his potentially career ending condition. Nothing worked the way he needed it to. After eight years of research he developed a formula that treats and prevents cold sores with daily use. It worked great and customers have thanked him for making it. We called it Lip Repair.
But he still wasn’t satisfied. He knew that if he kept working on it with our team of expert formulators they could make it even better. And they have!
Lip Repair Enhanced is the only lip balm that is great for your lips yet tough on your cold sores. With five anti-viral ingredients, you can use Lip Repair Enhanced daily to prevent cold sores from forming. And if you get one, you will be amazed at how fast your symptoms simply disappear! Simply apply it every waking hour and don’t use anything else. It even contains eight moisturizers that relieve dry, cracked and chapped lips and three anti-inflammatories that quickly reduce swelling.
So if you get cold sores, relax! We have you covered.
The following information was researched and prepared by Amanda Vickers, Director United States Botanical Safety Laboratory (USBSL) in a paper titled: “3-Fold Activity Robinson’s Remedies Lip Repair”. USBSL formulates our products.
I. Penetrate
St. John’s Wort (Hypericum perforatum in this case) has two well-known light- mediated anti-viral constituents, hypericin and pseudohypericin. Under ideal conditions (exposure to light), the antiviral effects of hypericin have been well- documented.1,2 It is likely that discrepancies existing in the clinical literature regarding antiviral activity of this ingredient, those which indicate a lack of HSV- inhibition for hypericin, are due to non-ideal conditions in which the hypericin was not photoactivated during treatment protocol.3,4 Robinson’s remedies uses a hydro- ethanolic extract of St. John’s Wort to rapidly penetrate the skin surface in addition to an infused oil of St. John’s Wort, suitable for the care of damaged, sensitive skin.
Lemonbalm (Melissa officinalis L.) is used as an antiviral, specifically for treating cold sores5. Lemonbalm has shown to prevent replication of herpes simplex virus type 2 in HEp-2 cells, as well as inhibit viral infectivity in both herpes simplex virus type 1 and 26. Lemonbalm is able to exert a direct antiviral effect on the herpes virus by affecting attachment and penetration of the virus to the host cells.7,8
The cellular ratio of the amino acids arginine and lysine has been shown in tissue culture studies to determine whether or not a virus is able to direct a host cell to create viral capsids at the expense of host cell histones5. In a lysine-heavy cell, viral replication is suppressed and the viral pathogenicity of the herpes simplex virus is greatly reduced.9 The inclusion of lysine, which is water-soluble, in a topical application, is intended to provide cells at the site of a herpes outbreak with a localized source of extracellular lysine in the event that these cells are lysine-poor.
The use of Glyceryl laurate in Robinson’s Remedies’® Lip Repair is three-fold. First, it is used as a co-emulsifer that has been shown to be nonirritating and is not a photosensitizer.10 Second, Glyceryl laurate helps penetrate through the skin’s surface. This helps carry active ingredients in the Lip Repair to treat the cold sore at its source. 11 Third, glyceryl laurate is known as monolaurin, a dietary supplement with GRAS (Generally Recognized As Safe) status by the Food and Drug Administration.12 Monolaurin has antibacterial and antivirial effects. Monolaurin has been shown to inactivate the lipid-coated viruses, such as the Herpes simplex virus.13,14
II. Protect
UV radiation damage is one trigger for sores of the lip and mouth region, including cold sore outbreaks and canker sores.15,16 Raspberry and coconut oils are natural plant oils with absorbance spectra in partially overlapping portions of the UV spectrum responsible for most sun-induced skin damage17. Robsinson’s Remedies makes no claims of a specific SPF; however, these oils’ primary role in the current formula is to protect skin from the stress caused by UV exposure–raspberry and coconut oils have nourishing and protective activities that may protect skin from the oxidative damage that normally occurs during UV radiation exposure.
Similarly, olive (Olea Europea) leaf extract also helps protect skin from stress caused by UV exposure. Olive leaf extract is the richest source in olive phenolic compounds such as oleuropein, hydroxytyrosol, and tyrosol. 18 “These phenolic compounds present antimicrobial, anticarcinogenic, anti-inflammatory and antioxidant activities”19.
Behenyl alcohol or Docosanol is a natural fatty alcohol that can be used as an alternative to wax and as an emulsifier. Docosanol has been reported to show substantial inhibitory effects on the replication of herpes simplex virus. 20 It is the active ingredient in the well-known antiviral Abreva ® . Docosanol protects the potential target cells by interfering with early intracellular events preventing viral entry and thus replication of the virus.21
Both tea tree (Melaleuca alternifolia) and peppermint (Mentha x piperita) essential oils are a widely recognized as having broad spectrum antimicrobial activity.22,23
Leucidal Liquid and AMTicide Coconut are included in the Robinson’s Remedies’ Lip Repair as natural preservatives. Leucidal Liquid is based on an antimicrobial peptide originally derived from Leuconostoc kimchii, which restricts microbial growth by acidifying its environment. Leucidal Liquid has also been shown to provide skin moisturization properties.24 AMTicide Coconut is created by fermenting Coconut (Cocos nucifera) fruit with Lactocacillus, which restricts fungal growth by disrupting the cellular structures of fungus. AMTicide Coconut also offers moisturizing and conditioning benefits.25
Butylated hydroxytoluene (BHT): The CRC Handbook (1992) classifies butylated BHT as an antioxidant, which is generally recognized as safe (USDA GRAS-listed) at the following levels:
• Food: <.02% total fat and oil (flavorings and essential oils can contain up to .5%)
• Drugs: <.2%
• Cosmetics: 0.01-0.1%
The FDA’s regulatory listing for injestible BHT lists a “no-effect” level as being equivalent to 50mg/kg of body weight per day. In the present formula, an entire 8- ml tube of lip repair contains approximately 8ug of BHT. With a “no-effect” level for a 70kg adult at 3500mg per day, consumption of an entire tube of Lip Repair would be on the order of 1/(4 X 106) of the “no effect” dose.
The information on the metabolism and toxicology of BHT is extensive. There is ample evidence of efficacy of this compound as an antioxidant. It has been suggested that BHT in fatty tissue may even have some effect similar to that of vitamin E. There are some data to indicate that BHT in diets reduces the incidence of certain tumors and the rate of fetal absorption in the rat. The available evidence does not support the view that BHT interferes in any specific way with cellular metabolism. There is no evidence that demonstrates that BHT causes frank biochemical lesions in the liver; moreover, it is obvious that high doses of BHT are needed to induce biochemical alterations. With 0.1% BHT in the diet in rats there are differing data in the literature concerning the effect of such treatment on liver growth and liver enzymes. At 0.05 % in the diet, no toxic effects are discernible. This “no-effect level” is equivalent to 50 mg per kg per day.26
A 1985 animal study evaluated the effect of topical treatment with BHT (5, 10, or 15%) on the recurrence and severity of lesion outbreaks in guinea pigs inoculated with genital herpes simplex virus, demonstrating a reduction in lesion duration during the first outbreak after inoculation:
“Treatment with placebo, 5%, 10%, or 15% BHT was initiated 48 h after viral inoculation and continued 4 times daily for 15 days. During primary infection no differences in maximum lesion severity or titers of virus in lesions were observed, however, lesion duration was reduced in BHT-treated animals resulting in a significantly smaller lesion score-day area under the reporting curve. In a second experiment using U.S.P. mineral oil as an additional placebo, BHT placebo and 15% BHT in a double blind trial, similar results were obtained.27”
In hairless mice infected with herpes simplex virus type 1, BHT was found to be effective in reducing the clearance time of cutaneous lesions when applied topically to the infected area (information on dosage not available to public at this time).28
III. Soothe
Arnica (Arnica MontanaI L.) flower infused oil makes up 2% of our total formula, or about 8% of our oil phase. In addition, we add a concentrated arnica flower CO2 extract to the arnica infused oil to increase potency. It must be noted that much of the literature finding inconclusive results for arnica in reduction of swelling and healing time is not conducted on a therapeutic dose of the plant constituents as is used in this formula, but on extremely dilute homeopathic preparations. Lip repair uses not homeopathic arnica, but a topical infused oil and CO2 extract. Extracts of arnica that include functional doses of the herb (between 1:10 and 1:100 herb weight to final volume) have been clinically shown to reduce painful swelling after surgeries and to increase healing time29,30. In this formula arnica is used to reduce painful swelling that accompanies early onset cold sores and to restore fluidity to the tissues surrounding a lesion.
Ahiflower ® (Buglossoides arvensis) seed oil is a safe and sustainable addition of essential Omega 3 fatty acids in Robinson’s Remedies Lip Repair. Omega 3s helps reduce inflammation, as well as moisturize your skin. 31,32
Glycerin is a naturally occurring sugar alcohol, which is one of the most commonly used and safe humectants, cosmetic ingredients that attract water from the air to the skin, causing a moisturizing effect. Glycerin is also more stable than water, and is bacteriostatic. Robinson’s Remedies uses only USP, vegetable-derived glycerin in Lip Repair and all its skin repair products. Glycerin is also approved by the FDA for use as a skin protectant active for use in the case of fever blisters and cold sores.
Glyceryl Stearate Citrate, Polyglyceryl-3 Stearate, Hydrogenated Lecithin and C12- 16 alcohols: These phospholipid emulsifiers create the creamy consistency of Lip Repair, and act as a protective second skin when applied to the lips, entrapping the nutritive and active oils of Lip Repair on the skin’s surface, while allowing the water- soluble lysine and St. John’s Wort extract to penetrate. Lysolecithin and Sclerotium Gum and Xanthan Gum and Pullulan also help to stabilize the emulsion, while providing a smooth, but non greasy feel on application.33 Potassium cetyl phosphate is an emulsifier and stabilizer, which are vital to a formulation to ensure that it maintains its homogenous mixture.
The herb responsible for the sweet flavor of Robinson’s Remedies’ Lip Repair is known as the sweet leaf, Stevia rebaudiana (Bertoni) Bertoni a plant of the Asteraceae family which is used in traditional cultures of Paraguay for sweetening teas such as yerba mate. Now, stevia is widely available under a plethora of brand names, with highly purified Rebaudioside A preparations being granted GRAS status in the US in 2009. Robinson’s Remedies uses a high quality food-grade stevia extract. In addition, stevia has been found to have anti-microbial and anti- inflammatory effects in vitro.34,35
Manuka honey is a monofloral honey, produced from the nectar of the Manuka honey bush, and is referred to as the “gold standard” of honey.36 The honey was added to Robinson’s Remedies’ Lip Repair to help soothe skin by decreasing inflammation and exudation that is common with cold sores. Honey has also been shown to be a safe and effective way to decrease the healing time of herpes simplex lesions. 37
TRADEMARKS
Robinson’s Remedies is a registered trademark of RR Health LLC
Abreva is a registered trademark of GlaxoSmithKline PLC
Ahiflower is a registered trademark of Technology Crops, LLC
Footnotes:
1 Hudson, J. B., I. Lopez-Bazzocchi, and G. H. N. Towers. “Antiviral activities of hypericin.” Antiviral research 15.2 (1991): 101-112.
2 Cohen, P. A., J. B. Hudson, and G. H. N. Towers. “Antiviral activities of anthraquinones, bianthrones and hypericin derivatives from lichens.” Experientia 52.2 (1996): 180-183.
3 Hudson, J. B., I. Lopez-Bazzocchi, and G. H. N. Towers. “Antiviral activities of hypericin.” Antiviral research 15.2 (1991): 101-112.
4 Lopez‐Bazzocchi, I., J. B. Hudson, and G. H. N. Towers. “Antiviral activity of the photoactive plant pigment hypericin.” Photochemistry and photobiology 54.1 (1991): 95-98.
5 Moradkhani, H., Sargsyan, E., Bibak, H., Naseri, B., Sadat-Hosseini, M., Fayazi-Barjin, A., & Meftahizade, H. (2010). Melissa officinalis L., a valuable medicine plant. J. Med. Plants Res, 4, 2753-2759.
6 Allahverdiyev, A., Duran, N., Ozguven, M., & Koltas, S. (2004). Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2. Phytomedicine, 11(7-8), 657-661.
7 Schnitzler, P., Schuhmacher, A., Astani, A., & Reichling, J. (2008). Melissa officinalis oil affects infectivity of enveloped herpesviruses. Phytomedicine, 15(9), 734-740.
8 Astani, A., Heidary Navid, M., & Schnitzler, P. (2014). Attachment and Penetration of Acyclovir‐resistant Herpes Simplex Virus are Inhibited by Melissa officinalis Extract. Phytotherapy research, 28(10), 1547-1552.
9 Griffith, RichardS, et al. “Success of L-lysine therapy in frequently recurrent herpes simplex infection.” Dermatology 175.4 (1987): 183-190.
10 Raposo, S., Salgado, A., Gonçalves, L., Pinto, P. C., Urbano, M., & Ribeiro, H. M. (2013). Safety assessment and biological effects of a new cold processed SilEmulsion for dermatological purpose. BioMed research international, 2013.
11 Final Report of the Amended Safety Assessment of Glyceryl Lau rate, Glyceryl Lau rate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate1. (2004). International Journal of Toxicology, 23(2_suppl), 55–94. doi: 10.1080/10915810490499064
12 CHAPTER, I. CFR-Code of Federal Regulations Title 21.
13 Lieberman, S., Enig, M. G., & Preuss, H. G. (2006). A review of monolaurin and lauric acid: natural virucidal and bactericidal agents. Alternative & Complementary Therapies, 12(6), 310-314.
14 HIERHOLZER, J. C., & KABARA, J. J. (1982). IN VITRO EFFECTS OF MONOLAURIN COMPOUNDS ON ENVELOPED RNA AND DNA VIRUSES 1. Journal of Food Safety, 4(1), 1-12.
15 Wheeler Jr, Clayton E. “The herpes simplex problem.” Journal of the American Academy of Dermatology 18.1 (1988): 163-168.
16 Esmann, Jørgen. “The many challenges of facial herpes simplex virus infection.” Journal of antimicrobial Chemotherapy 47.suppl 1 (2001): 17-27.
7 Schnitzler, P., Schuhmacher, A., Astani, A., & Reichling, J. (2008). Melissa officinalis oil affects infectivity of enveloped herpesviruses. Phytomedicine, 15(9), 734-740.
8 Astani, A., Heidary Navid, M., & Schnitzler, P. (2014). Attachment and Penetration of Acyclovir‐resistant Herpes Simplex Virus are Inhibited by Melissa officinalis Extract. Phytotherapy research, 28(10), 1547-1552.
9 Griffith, RichardS, et al. “Success of L-lysine therapy in frequently recurrent herpes simplex infection.” Dermatology 175.4 (1987): 183-190.
10 Raposo, S., Salgado, A., Gonçalves, L., Pinto, P. C., Urbano, M., & Ribeiro, H. M. (2013). Safety assessment and biological effects of a new cold processed SilEmulsion for dermatological purpose. BioMed research international, 2013.
11 Final Report of the Amended Safety Assessment of Glyceryl Lau rate, Glyceryl Lau rate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate1. (2004). International Journal of Toxicology, 23(2_suppl), 55–94. doi: 10.1080/10915810490499064
12 CHAPTER, I. CFR-Code of Federal Regulations Title 21.
13 Lieberman, S., Enig, M. G., & Preuss, H. G. (2006). A review of monolaurin and lauric acid: natural virucidal and bactericidal agents. Alternative & Complementary Therapies, 12(6), 310-314.
14 HIERHOLZER, J. C., & KABARA, J. J. (1982). IN VITRO EFFECTS OF MONOLAURIN COMPOUNDS ON ENVELOPED RNA AND DNA VIRUSES 1. Journal of Food Safety, 4(1), 1-12.
15 Wheeler Jr, Clayton E. “The herpes simplex problem.” Journal of the American Academy of Dermatology 18.1 (1988): 163-168.
16 Esmann, Jørgen. “The many challenges of facial herpes simplex virus infection.” Journal of antimicrobial Chemotherapy 47.suppl 1 (2001): 17-27.
17 Oomah, B. Dave, et al. “Characteristics of raspberry (< i> Rubus idaeus</i> L.) seed oil.” Food Chemistry 69.2 (2000): 187-193.
18 De Bock, M., Thorstensen, E. B., Derraik, J. G., Henderson, H. V., Hofman, P. L., & Cutfield, W. S. (2013). Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract. Molecular nutrition & food research, 57(11), 2079-2085.
19 Ribeiro, Ana Sofia, et al. “Main benefits and applicability of plant extracts in skin care products.” Cosmetics 2.2 (2015): 48-65.
20 Katz, D. H., Marcelletti, J. F., Khalil, M. H., Pope, L. E., & Katz, L. R. (1991). Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex. Proceedings of the National Academy of Sciences, 88(23), 10825-10829.
21 Pope, L. E., Marcelletti, J. F., Katz, L. R., Lin, J. Y., Katz, D. H., Parish, M. L., & Spear, P. G. (1998). The anti-herpes simplex virus activity of n-docosanol includes inhibition of the viral entry process. Antiviral research, 40(1-2), 85-94.
22 Cox, S. D., et al. “The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil).” Journal of applied microbiology 88.1 (2000): 170-175.
23 Hammer, Katherine A., C. F. Carson, and T. V. Riley. “Antimicrobial activity of essential oils and other plant extracts.” Journal of applied microbiology 86.6 (1999): 985-990.
24 Leucidal® Liquid. (n.d.). Retrieved from https://activemicrotechnologies.com/product/leucidal-liquid/
25 AMTicide® Coconut. (n.d.). Retrieved from https://activemicrotechnologies.com/product/ amticide-coconut/
26 Butylated Hydroxytoluene—FDA Proposed Rule, Vol 42, No. 104, Federal Register, page 27606, May 1977
27 Richards, James T., Mary Ellen Katz, and Earl R. Kern. “Topical butylated hydroxytoluene treatment of genital herpes simplex virus infections of guinea pigs.” Antiviral research 5.5 (1985): 281-290.
28 Keith, Alec D., et al. “The antiviral effectiveness of butylated hydroxytoluene on herpes cutaneous infections in hairless mice.” Experimental Biology and Medicine 170.2 (1982): 237-244.
29 Huber, Roman, et al. “Arnica and stinging nettle for treating burns–A self- experiment.” Complementary therapies in medicine 19.5 (2011): 276-280.
30 Kučera, Miroslav, et al. “Arnica/Hydroxyethyl salicylate combination spray for ankle distortion: A four-arm randomised double-blind study.” Pain research and treatment 2011 (2011).
31 Cumberford, G., & Hebard, A. (2015). Ahiflower oil: A novel non‐GM plant‐ based omega‐3+ 6 source. Lipid Technology, 27(9), 207-210.
32 Prasad, P., Savyasachi, S., & Reddy, L. P. A. (2019). Physico-chemical Characterization, Profiling of Total Lipids and Triacylglycerol Molecular Species of Omega-3 Fatty Acid Rich B. arvensis Seed Oil from India. Journal of oleo science, 68(3), 209-223.
33 Moldovan, M., Lahmar, A., Bogdan, C., Părăuan, S., TOMUŢĂ, I., & CRIŞAN, M. (2017). Formulation and evaluation of a water-in-oil cream containing herbal active ingredients and ferulic acid. Clujul Medical, 90(2), 212.
34 Jayaraman, Sathishkumar, Muthu Saravanan Manoharan, and Seethalakshmi Illanchezian. “In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts.” Tropical Journal of Pharmaceutical Research 7.4 (2008): 1143-1149.
35 Boonkaewwan, Chaiwat, Chaivat Toskulkao, and Molvibha Vongsakul. “Anti- inflammatory and immunomodulatory activities of stevioside and its metabolite steviol on THP-1 cells.” Journal of agricultural and food chemistry 54.3 (2006): 785- 789.
36 Ahmed, S., & Othman, N. H. (2013). Review of the medicinal effects of tualang honey and a comparison with manuka honey. The Malaysian journal of medical sciences: MJMS, 20(3), 6.
37 Al-Waili, N. S. (2004). Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions. Medical Science Monitor, 10(8), MT94-MT98.
When should I use LIP REPAIR ENHANCED?
Lip Repair Enhanced may be used regularly as any normal lip balm. If you have a cold sore or feel one coming, apply every waking hour. Do not use other remedies including prescriptions as they may inhibit the efficacy of Lip Repair.
How do I apply LIP REPAIR ENHANCED?
Apply with the slanted applicator tip, a clean finger or with a Q-Tip.
Can I use LIP REPAIR ENHANCED if I already have a cold sore?
Yes. LIP REPAIR works even after a blister has developed. Apply it at least every waking hour making sure not to use any other remedy including prescription medication. These may lessen Lip Repair’s effectiveness.
Will LIP REPAIR ENHANCED help to prevent future outbreaks?
Yes, when used daily.
How does LIP REPAIR ENHANCED differ from other cold sore products?Lip Repair Enhanced is formulated to PREVENT cold sores with daily use. It has ingredients that only treat cold sores, but make your lips feel soft and supple.
What are the ingredients in LIP REPAIR ENHANCED?
Please refer to the scientific paper which not only lists our ingredients but the scientific reason for including them in our formulation.
Is LIP REPAIR ENHANCED tested on animals?
No, LIP REPAIR does not participate in animal testing.
Can I wear lipstick while using LIP REPAIR ENHANCED?
Yes, apply LIP REPAIR first, let your lips absorb the product before applying lipstick.
Can I use LIP REPAIR ENHANCED if I don’t have a cold sore?
Yes, use LIP REPAIR to moisturize and prevent dry, cracked and chapped lips.
COPING WITH COLD SORE OUTBREAKS
By KEN ROBINSON – founder of Robinson’s Remedies
Cold sores have been plaguing people of all ages, races, and lifestyles since the late 1800’s. Also known as fever blisters, cold sores are medically referred to as the Herpes Simplex Virus (HSV-1). HSV-1 is commonly recognized as a series of small blisters that form on the lips or around the corner of the mouth. Throughout the duration of the illness, these blisters will bubble, break open and leak a clear fluid, eventually resulting in a scab after a few days. Left untreated, the blisters commonly take approximately three weeks to completely heal from the onset of each episode.
HSV-1 is known to be extremely contagious and can be contracted from an intimate interaction with an infected patient. After the disease is contracted, it lays dormant in the upper part of the spine until reappearing as a flare up. Flare ups are not the same for every patient: each individual will react differently to the virus. Some with HSV-1 are immune to the virus, while others will suffer from several outbreaks a year. Several factors will encourage viral growth and cause an outbreak, including stress, illness, injury, a weakened immune system, or too much exposure to sunlight. When a patient has too much of the amino acid arginine along with too little of the amino acid lysine, outbreaks can occur as well.
Diet can also play a large role when triggering an outbreak. An overly acidic system – drinking orange juice, consuming sugar – are great catalysts to the outbreak of a cold sore. By incorporating foods rich in lysine into the diet, including most fresh vegetables and fruits, a patient can prevent outbreaks. Lysine-rich foods include pears, figs, tomatoes and apricots. A balanced mix of dairy, protein and chicken or vegetable broth has also helped with preventative methods of consistent outbreaks.
Positive ions can also make your body viral. Positive ions are found in the aftermath of a thunderstorm. In fact, most home air purifiers have a built-in negative ion generator, which is another preventative method to take.
At the onset of a cold sore, a lipid envelope surrounds the virus, which makes it harder for any chemical to reach and treat the virus directly. Robinson’s Remedies Lip Repair contains a unique formula that naturally penetrates this lipid envelope, in turn rapidly relieving the symptoms of a cold sore. Using Robinson’s Remedies Lip Repair daily will create an unwelcome environment for a cold sore.
Unfortunately there isn’t a cure for HSV-1, but that doesn’t mean you have to be prisoner to the disease. Figure out what makes you happy, learn how to live with less stress, know your triggers, and act quickly at the onset of an outbreak. A healthy combination of all these elements will make living with HSV-1 completely manageable.